In April 1953, the Northeast Chemical Bureau Design Company Research Office and the Zhejiang Province Chemical Experiment Institute merged to become the Beijing Chemical Experimental Institute of the Central Heavy Industry Department Chemical Bureau, with substations at Shenyang and Hangzhou.

In February 1954, the Beijing Institute, along with the Hangzhou and Shenyang Substations merged to become the Central People’s Government Heavy Industry Department’s Chemical Bureau Chemical Industry Experimental Institute. The name was later shortened to Shenyang Chemical Industry Experimental Institute.

In January 1955, the Central Heavy Industry Department’s Chemical Industry Bureau directed merger of the Shenyang Dyestuff Factory with the Pilot Plant of Shenyang Chemical Industry Experimental Institute, and renamed the Shenyang Chemical Industry Experimental Institute as the Central Heavy Industry Department Northeast Chemical Industry Bureau’s Chemical Industry Comprehensive Research Institute.

In September 1956, following establishment of the Chemical Mimistry, Shenyang Chemical Industry Comprehensive Research Institute was renamed Shenyang Research Institute of Chemical Industry (SYRICI). SYRICI was divided into four parts. The Laboratory of the Chemical Fertilizer Department was moved to Shanghai where it merged with the Tianli Chemical Factory and the Shanghai Acid Factory to become the Shanghai Research Institute of Chemical Industry.

In December 1957, the Ministry of Chemical Industry directed the Inorganic Lab and the Oil Paint Lab of the Shenyang Research Institute of Chemical Industry to move to Tianjin where it merged with the Tianjin Research Institute of Chemical Industry and the Yongming Oil Paint Factory to become the Tianjin Research Institute of Chemical Industry. Operations related to plastics, rubber, macromolecules, organic synthesis， chemical industry, physical chemistry, analysis, and information reporting were moved to Beijing, and the Beijing Research Institute of Chemical Industry was established.

In May 1958, the Shenyang Research Institute of Chemical Industry was renamed Beijing Research Institute of Chemical Industry, Shenyang Substation. The Shenyang Substation was designated to concentrate on agrichemicals and dyestuffs, while retaining some responsibilities in plastics, macromolecules, chemical industry, and other areas.

In 1960, SYRICI was still administered by the Ministry of Chemical Industry, and was called the Shenyang Research Institute of Chemical Industry.

From 1956 to 1966, the Ministry of Chemical Industry directed petrochemicals, anti-corrosion, and a portion of meter automation to move from Shenyang Research Institute of Chemical Industry to Lanzhou where these operations were transferred to the merged Lanzhou Chemical Company Research Institute and Chemical Equipment Institute. A portion of National Defense was moved to Qinghai where Liming Research Institute of Chemical Industry was established. Portions of organic silicones and engineering plastics were moved to Sichuan where Chenguang Research Institute of Chemical Industry was established.

In October 1970, administration of SYRICI was transferred to the provincial level, and was placed under the Liaoning Provincial Petrochemical Bureau’s Shenyang Research Institute of Chemical Industry.

In January 1978, the Ministry of Chemical Industry returned Shenyang Research Institute of Chemical Industry to its own administration.

In 1987, the Ministry of Chemical Industry decided to discontinue light sensing research at the institute, and to establish the Light Sensing Technology and Materials Research and Development Center of the Ministry of Chemical Industry.

In May 1999, the State Council approved the transformation of Shenyang Research Institute of Chemical Industry into a “Central Large-scale Science and Technology Enterprise” under the Central Enterprise Work Council.

In March 2003, as a Central Large-scale Science and Technology Enterprise, SYRICI was placed under the State-Owned Assets Supervision and Administration Commission of the State Council.